Kleine levin syndrome is a rare disorder characterized by recurrent episodes of excessive sleep hypersomnia along with cognitive and behavioral changes. Sindromul kleine levin a fost descris pentru prima data in anul. Assim, o apoio da familia e educacao sao a melhor gestao disponivel no momento. Kleinelevin syndrome kls is a rare sleep disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. Kleine levin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleine levin syndrome are male. Sindromul kleine levin sindromul kleine levin critchley. Pdf kleinelevin syndrome kls is a rare disorder with symptoms that include periodic hypersomnia, cognitive and behavioural disturbances. This has been an on going battle for over 3 years now.
Kleine levin syndrome kls kleine levin syndrome kls is a chronic sleep disorder and is one of the central disorders of hypersomnolence cdhs. Kleinelevin syndrome diagnosis stanford health care. Pathophysiologic hypotheses include a hypothalamic dysfunction and abnormalities in the central serotonin and dopamine metabolism. We collected detailed clinical data and blood samples on 108 patients, 79 parent pairs, and 108 matched control subjects. Kleinelevin syndrome, sometimes referred to as rip van winkle disease, is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioural and cognitive disturbances, hyperphagia and in some cases hypersexuality. Associated symptoms include an abnormally uninhibited sex drive, irritability, and disorientation. Kleinelevin syndrome kls is a rare sleep disorder mainly affecting teenage. Forgotten diseases research foundation kleinelevin. Diagnosing kls is admittedly a challenge but can be a relief for a family in search of answers. Kleinelevin syndrome is a rare recurrent hypersomnia associated with symptoms of behavioral and cognitive impairment.
Kleine levin syndrome kls is a rare disease characterized by recurrent episodes of hypersomnia and, to various degrees, behavioural or cognitive disturbances, compulsive eating behaviour and hypersexuality american academy of sleep medicine, 2005. Kleine levin syndrome kls, also called recurrent hypersomnia, is a rare sleep disorder characterized by recurrent episodes of severe hypersomnia associated with cognitive and behavioral disturbances such as confusion, derealization, apathy, compulsive eating, and hypersexuality. These episodes usually last for a few days to a few weeks. My 16 year old son was recently diagnosed with kleine levin syndrome kls. Diagnosis, disease course, and management of patients with kleine. Kleine levin syndrome is a rare disorder characterized by relapsingremitting episodes of hypersomnia, cognitive disturbances, and behavioral disturbances, such as hyperphagia and hypersexuality. To compare the benefits and risks of lithium therapy vs abstentionother treatments in kleinelevin syndrome kls. Home about us rare disesases global growth curves calculators contact donate. Kleinelevin syndrome kls is a rare sleep disorder characterized by recurrent and unusually long episodes of hypersomnia, associated with behavioralcognitive disturbances, megaphagia and more rarely sexual disinhibition.
In a kls cohort followed in a single center, patients regularly took lithium carbonate median dose 1,000 mgday. Affected individuals may sleep for up to 20 hours per day during an episode. Penderita bisa tertidur selama berjamjam, berharihari, bermingguminggu, bahkan bisa berbulanbulan, tergantung pada berapa lama penyakit itu munculkambuh. Tidur seharian saja capeknya bukan main, gimana kalau seminggu atau sebulan. Sindromul kleine levin o forma speciala a hipersomniei o constituie sindromul kleine levin, care afecteaza tinerii intre 10. Kleine levin syndrome kls is a rare disease characterized by recurrent episodes of severe hypersomnia as well as cognitive, behavioral, and psychological disturbances. Kleinelevin syndrome kls is a rare sleep disorder mainly.
Kleine levin syndrome, sometimes referred to as rip van winkle disease, is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence. Jan 20, 2014 kleinelevin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment. Kleinelevin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment. Kleinelevin syndrome is a rare disorder characterized by the need for excessive amounts of sleep hypersomnolence, i. Kleinelevin syndrome nord national organization for. Kleinelevin syndrome information page national institute. Kleinelevin syndrome kls is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hypersexuality. Kleinelevin syndrome is a rare sleep disorder that mainly affects adolescents and is characterised by. Kleinelevin syndrome kls is a sleep disorder that is characterized by recurring episodes of excessive sleep. Kleine levin syndrome diagnosis diagnosing kleine levin syndrome. Many patients also experience hyperphagia, hypersexuality and other symptoms. Kleinelevin syndrome kls is a rare disorder characterized by discrete episodes of hypersomnia associated with cognitive and behavioural abnormalities, as well as normal alertness and function between episodes. Each episode is of brief duration varying from a week to 12 months and affected people are entirely.
Mungkin seolah sebuah cerita dongeng, namun penyakit tidur bak kisah putri aurora ini rupanya benarbenar ada di dunia. Introduction kleine levin syndrome kls is a rare sleep disorder that affects 1 person in a million and has been suggested to be more frequent in ashkenazi jewish. The disorder strikes adolescents primarily but can occur in younger children and adults. Sindromul kleine levin kls este o tulburare a somnului rara, caracterizata prin hipersomnie episodica persistenta. Several clinical symptoms also suggest an underlying autoimmune process. I also have a daughter that was diagnosed with narcolepsy at around age 1617, but had symptoms years prior to being diagnosed. All books are in clear copy here, and all files are secure so dont worry about it. This term refers to conditions that cause excessive daytime sleepiness, meaning. Essa sindrome foi descoberta por dois cientistas, chamados kleine e levin, entre 1925 e 1929. Symptoms occur as episodes, typically lasting a few days to a few weeks. Request pdf kleinelevin syndrome kleinelevin syndrome is a rare recurrent hypersomnia associated with symptoms of behavioral and cognitive impairment. Kleinelevin syndrome, hypersomnia, adolescent sleep disorder, hypersexuality.
Sindrom kleine levin adalah penyakit yang masih misterius. Because its primary symptom, hypersomnia, is common to a number of disorders, the process by which we diagnose kls is one of exclusion ruling out other conditions that share. Pdf kleinelevin syndrome kls is the commonest recurrent sleep disorder with a prevalence of 12 per million population. Kleinelevin syndrome is potentially rich in behavioral, cognitive, and mental symptoms. Kleinelevin syndrome kls is a rare disorder that causes recurring periods of excessive sleepiness. To systematically investigate patients with kls with reference to the available. Kleine levin syndrome kls is a rare disorder characterized by periodic hypersomnia associated with behavioural disturbances such as binge eating hyperphagia, irritability, and increased sexual interest hyper sexuality. This site is like a library, you could find million book here by using search box in the.
Kleinelevin syndrome kls is a rare disorder of unknown etiology. Jul 10, 2017 kleine levin syndrome is a rare disorder characterized by recurrent episodes of excessive sleep hypersomnia along with cognitive and behavioral changes. Kleinelevin syndrome an overview sciencedirect topics. Treatments for kleinelevin syndrome stanford health care. Kleinelevin syndrome kls is a rare disorder with periodic.
These serious episodes alternate with periods without any symptoms. Most often an affliction that affects adolescent males, the episodes may come out of nowhere and affect your loved one for a few days or a few weeks. Kleinelevin syndrome kls is a rare disease characterized by recurrent episodes of hypersomnia and to various degrees, behavioral or cognitive disturbances, compulsive eating behavior, and hypersexuality. To systematically investigate patients with kls with reference to the available hypotheses. The disease predominantly affects adolescent males. Because its primary symptom, hypersomnia, is common to a number of disorders, the process by which we diagnose kls is one of exclusion ruling out other conditions that share symptoms. Kleine levin syndrome genetic and rare diseases information. Juga dikenal sebagai sindrom tidur nyenyak, sindrom kleine levin adalah gangguan asal neurologis yang ditandai dengan adanya episode hipersomnia yang mendalam, di mana individu bisa tidur hingga dua puluh jam berturutturut. Kleine levin syndrome kls foundationss first international conference.
Selain hipersomnia, kehadiran sindrom ini merupakan ciri khas dari sindrom ini. Kleine levin syndrome is a rare disorder characterized by relapsing. In some cases, this means up to 20 hours a day are spent sleeping. Mar 27, 2019 kleine levin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleine levin syndrome are male. Kleinelevin syndrome is a rare disorder characterized by. Kls is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, and a reduced understanding of the world where the patient becomes progressively drowsy and sleeps for most of the day and night, sometimes waking only to eat or use the bathroom. Kleine levin syndrome disingkat kls adalah penyakit saraf yang langka dimana penderita tidak bisa mengontrol rasa kantuknya. Kleine levin syndrome kls is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, and a reduced understanding of the world. Some aspects of the disease can be managed with medication, such as stimulants to combat the eds, but this is most effective only once the episodes have already decreased in severity. Patients generally experience recurrent episodes of the condition for more than a decade and may return at a later age. Learn about kleinelevin syndrome, a disorder characterized by recurring episodes of excessive sleep up to 20 hours per day.